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Generalized Pustular Psoriasis 

Generalized Pustular Psoriasis (GPP) is a rare and severe form of psoriatic disease. It is characterized by painful and widespread eruptions of sterile pustules (blisters filled with pus), often accompanied by fever, pain, and redness. GPP can emerge suddenly and may require urgent medical treatment.

WHO IS AFFECTED?

Though it’s rare, GPP can appear in about 3% of people with recognized psoriatic disease but may also affect individuals with no prior history of psoriasis

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Symptoms of GPP

  • Widespread, pus-filled blisters that may burst, leaving raw, painful skin.
  • Accompanied by fever, shivering, and physical discomfort.
  • Redness of the skin (erythema) occurs, followed by the formation of pustules.
  • The pustules can combine and erupt, creating a harmful cycle of skin damage.

Causes and Triggers

  • Sudden corticosteroid withdrawal as it can create a rebound effect
  • Infections
  • Certain medical conditions
  • Emotional stress

Emotional and Mental Impact

Living with GPP is not just physically painful; it can also be emotionally overwhelming. Emotional burden may include

  • Pain and distress

  • Anxiety

  • Sense of guilt feeling that you brought on the disease = which is a myth

  • Social stigma 

  • Difficulty sleeping

  • Tension around relationships

  • Worries about employment

  • Concerns about future flares

Treatment Options South Africa

  • Topical steroids applied on the body with wraps – such as clobetasol or fluocinolone
  • Systemic medication – such as methotrexate, prednisone, acitretin, cyclosporine – given orally

Biologics are used when available

in a million people are diagnosed with Generalized Pustular Psoriasis annually worldwide

% of GPP cases present with acute flares that can be life-threatening without proper treatment

% of GPP patients experience recurring flares, causing severe pain, fatigue, and emotional distress

% of misdiagnosed GPP cases face treatment delays, increasing the risk of complications

Tips for Managing GPP

  • Work closely with your healthcare provider to create a personalized treatment and maintenance plan.
  • Avoid known triggers like sudden steroid withdrawal and manage any existing comorbidities (e.g., diabetes).
  • Ensure ongoing care, including regular follow-up appointments and maintaining a moisturizing routine​

Common Misconceptions

  • GPP is NOT contagious: Despite the presence of pus, GPP is not caused by bacteria and cannot be spread from person to person.
  • GPP is NOT your fault: It results from an abnormal autoimmune response and is not caused by anything you did or didn’t do.

YOU ARE NOT ALONE!

If you or a loved one is dealing with Generalized Pustular Psoriasis (GPP), remember that you are not alone. It’s essential to seek medical attention for proper diagnosis and treatment, as GPP can escalate quickly. Reach out to a healthcare professional, and don’t hesitate to connect with our community for support and resources. We’re here to help you navigate this condition with shared experiences.